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Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes
- Source :
- Data in Brief, Data in Brief, Vol 6, Iss, Pp 715-721 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (http://www.ebi.ac.uk/pride/archive/projects/PXD002319-http://www.ebi.ac.uk/pride/archive/projects/PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1]. Keywords: Proteomics, Metazoa, Protein complexes, Biochemical, Fractionation
- Subjects :
- 0301 basic medicine
Proteomics
Protein complexes
Computational biology
Bioinformatics
lcsh:Computer applications to medicine. Medical informatics
Dictyostelium discoideum
Biochemical
03 medical and health sciences
Interaction network
Fractionation
lcsh:Science (General)
Caenorhabditis elegans
Data Article
Multidisciplinary
biology
Metazoa
biology.organism_classification
Strongylocentrotus purpuratus
030104 developmental biology
Homo sapiens
Proteome
lcsh:R858-859.7
Drosophila melanogaster
lcsh:Q1-390
Subjects
Details
- ISSN :
- 23523409
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....133234cd9c939e24138ab5bca37cd76b
- Full Text :
- https://doi.org/10.1016/j.dib.2015.11.062