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The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease
- Source :
- University of Bristol-PURE, Scopus-Elsevier
- Publication Year :
- 2016
-
Abstract
- Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p
- Subjects :
- Apolipoprotein E
Male
medicine.medical_specialty
Genotype
Apolipoprotein E4
Genetic determinism
Apolipoproteins E
Alzheimer Disease
Internal medicine
Genetics
medicine
Humans
Allele
Allele frequency
Genetics (clinical)
Butyrylcholinesterase
Alleles
Cholinesterase
Aged
biology
Genetic Variation
Middle Aged
medicine.disease
Endocrinology
biology.protein
lipids (amino acids, peptides, and proteins)
Female
Disease Susceptibility
Alzheimer's disease
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- University of Bristol-PURE, Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....133962c9c11c49d4e0814dadf510b6a2