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Discontinuous calcitonin treatment of established osteoporosis--effects of withdrawal of treatment
- Source :
- The American journal of medicine. 89(1)
- Publication Year :
- 1990
-
Abstract
- purpose: The purpose of this study was to examine the effects of discontinuous treatments with intranasal salmon calcitonin on bone and calcium metabolism in postmenopasal women and to establish the effects of withdrawing treatment. patients and methods: This report presents data from 26 postmenopausal women with established osteoporosis (forearms fracture) 12 months after withdrawal of a 1-year double-blind, placebo-controlled therapy with intranasal calcitonin. The women then resumed treatment with calcitonin 200 IU plus calcium 500 mg daily in an open design for an additional 1-year period. A control group of 19 age-matched women (no forearms fracture) did not receive any treatment. results: At the end of the 3 years, the control group had lost significantly more bone in the forearm (single photon absorptiometry) and spine (dual photon absorptiometry) than had the group treated with intranasal calcitonin for 2 years, whereas the group receiving calcitonin for 1 year had intermediate values. During the year of withdrawal, the rate of bone loss was similar in the women who had received calcitonin and those who had received placebo. Calcitonin was especially effective in women with initially high bone turnover and low bone mass. The bone response in the spine could, furthermore, be estimated by the changes in bone turnover. conclusion: Discontinuous treatment with intranasal calcitonin affects bone and calcium metabolism in established osteoporosis. In women with high-turnover osteoporosis, therapy results in a net gain of bone in both the peripheral and axial skeleton. Response to treatment may be monitored by changes in bone turnover.
- Subjects :
- Calcitonin
medicine.medical_specialty
Osteoporosis
Osteocalcin
chemistry.chemical_element
Calcium
Placebo
Bone and Bones
Bone remodeling
Absorptiometry, Photon
Forearm
Bone Density
Internal medicine
medicine
Humans
Administration, Intranasal
Osteoporosis, Postmenopausal
Aged
Calcium metabolism
Lumbar Vertebrae
business.industry
General Medicine
Middle Aged
medicine.disease
Alkaline Phosphatase
Hydroxyproline
Endocrinology
medicine.anatomical_structure
chemistry
Creatinine
Nasal administration
Female
business
Subjects
Details
- ISSN :
- 00029343
- Volume :
- 89
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The American journal of medicine
- Accession number :
- edsair.doi.dedup.....13409ff19b4bb0594971f13d7604a15a