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Cloning of the rat Gadd45 cDNA and its mRNA expression in the brain
- Source :
- Gene. 151(1-2)
- Publication Year :
- 1994
-
Abstract
- We cloned the rat Gadd45 (growth arrest and DNA damage inducible) cDNA and examined its mRNA induction by y-ray irradiation in the rat brain. The rat Gadd45 cDNA sequence was highly homologous to the previously published human and hamster cDNAs, and was partially similar to the 28S rRNA gene. The mRNA encoding rat GADD45 was induced in the brain after γ-ray irradiation. This finding indicates that Gadd45 is an inducible gene following the ionizing radiation, not only in cultured cells in vitro, but also in animal tissues in vivo.
- Subjects :
- DNA, Complementary
DNA damage
Molecular Sequence Data
Hamster
Gene Expression
Biology
Polymerase Chain Reaction
law.invention
law
Complementary DNA
Cricetinae
Sequence Homology, Nucleic Acid
Genetics
Animals
Amino Acid Sequence
RNA, Messenger
Cloning, Molecular
Gene
DNA Primers
Cloning
Messenger RNA
Base Sequence
cDNA library
Intracellular Signaling Peptides and Proteins
Brain
Proteins
General Medicine
Molecular biology
Rats
Gamma Rays
Protein Biosynthesis
Recombinant DNA
DNA Damage
Subjects
Details
- ISSN :
- 03781119
- Volume :
- 151
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....1359552c8d7e236c2ba8eaf3fa0e299f