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Common variants at 12q14 and 12q24 are associated with hippocampal volume
- Source :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2012, 44 (5), pp.545-551. ⟨10.1038/ng.2237⟩, Nature Genetics, 2012, 44 (5), pp.545-551. ⟨10.1038/ng.2237⟩, Nature genetics, 44(5), 545-551. Nature Publishing Group, Bis, J C, DeCarli, C S, Vernon Smith, A, van der Lijn, F, Crivello, F, Fornage, M, Debette, S, Shulman, J M, Schmidt, H, Srikanth, V, Schuur, M, Yu, L, Choi, S, Sigurdsson, S, Verhaaren, B F J, DeStefano, A L, Lambert, J C, Jack, C R J, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, C A, Fleischman, D, Zijdenbos, A, den Heijer, T, Mazoyer, B, Coker, L H, Enzinger, C, Danoy, P, Amin, N, Arfanakis, K, van Buchem, M A, de Bruijn, R F A G, Beiser, A, Dufouil, C, Huang, J, Cavalieri, M, Thomson, R, Niessen, W J, Chibnik, L B, Gislason, G K, Hofman, A, Pikula, A, Amouyel, P, Freeman, K B, Phan, T G, Oostra, B A, Stein, J L, Medland, S E, Vasquez, A A, Hibar, D P, Wright, M J, Franke, B, Martin, N G, Thompson, P M, Hottenga, J J, Boomsma, D I, Nalls, M A, Uitterlinden, A G, Au, R, Elbaz, A, Beare, R J, van Swieten, J C, Lopez, O L, Harris, T B, Chouraki, V, Breteler, M M B, de Jager, P L, Becker, J T, Vernooij, M W, Knopman, D, Fazekas, F, Wolf, P A, van der Lugt, A, Gudnason, V, Longstreth, J W T, Brown, M A, Bennett, D A, van Duijn, C M, Mosley, T H, Schmidt, R, Tzourio, C, Launer, L J, Arfan Ikram, M & Seshadri, S 2012, ' Common variants at 12q14 and 12q24 are associated with hippocampal volume ', Nature Genetics, vol. 44, no. 5, pp. 545-551 . https://doi.org/10.1038/ng.2237, Nature Genetics, 44(5), 545, Nature Genetics, 44, 5, pp. 545-51, Nature Genetics, 44(5), 545-551. Nature Publishing Group, Nature genetics, Nature genetics 44(5), 545-551 (2012). doi:10.1038/ng.2237, Nature Genetics, 44, 545-51
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- Contains fulltext : 110608.pdf (Publisher’s version ) (Closed access) Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of
- Subjects :
- Netherlands Twin Register (NTR)
genetics [Alzheimer Disease]
Genome-wide association study
DCN PAC - Perception action and control
genetics [Cognition Disorders]
Hippocampal formation
Hippocampus
0302 clinical medicine
Polymorphism (computer science)
Cognitive decline
Genetics
0303 health sciences
Translational research Immune Regulation [ONCOL 3]
Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]
genetics [Chromosomes, Human, Pair 12]
genetics [Polymorphism, Single Nucleotide]
Alzheimer's disease
Genetic Markers
medicine.medical_specialty
DCN MP - Plasticity and memory
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Article
Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]
03 medical and health sciences
Meta-Analysis as Topic
SDG 3 - Good Health and Well-being
genetics [Dementia]
Alzheimer Disease
ddc:570
Internal medicine
medicine
Humans
SNP
Chromosome 12
030304 developmental biology
Chromosomes, Human, Pair 12
[SCCO.NEUR]Cognitive science/Neuroscience
medicine.disease
Endocrinology
Genetic Loci
physiopathology [Hippocampus]
Dementia
Cognition Disorders
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2012, 44 (5), pp.545-551. ⟨10.1038/ng.2237⟩, Nature Genetics, 2012, 44 (5), pp.545-551. ⟨10.1038/ng.2237⟩, Nature genetics, 44(5), 545-551. Nature Publishing Group, Bis, J C, DeCarli, C S, Vernon Smith, A, van der Lijn, F, Crivello, F, Fornage, M, Debette, S, Shulman, J M, Schmidt, H, Srikanth, V, Schuur, M, Yu, L, Choi, S, Sigurdsson, S, Verhaaren, B F J, DeStefano, A L, Lambert, J C, Jack, C R J, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, C A, Fleischman, D, Zijdenbos, A, den Heijer, T, Mazoyer, B, Coker, L H, Enzinger, C, Danoy, P, Amin, N, Arfanakis, K, van Buchem, M A, de Bruijn, R F A G, Beiser, A, Dufouil, C, Huang, J, Cavalieri, M, Thomson, R, Niessen, W J, Chibnik, L B, Gislason, G K, Hofman, A, Pikula, A, Amouyel, P, Freeman, K B, Phan, T G, Oostra, B A, Stein, J L, Medland, S E, Vasquez, A A, Hibar, D P, Wright, M J, Franke, B, Martin, N G, Thompson, P M, Hottenga, J J, Boomsma, D I, Nalls, M A, Uitterlinden, A G, Au, R, Elbaz, A, Beare, R J, van Swieten, J C, Lopez, O L, Harris, T B, Chouraki, V, Breteler, M M B, de Jager, P L, Becker, J T, Vernooij, M W, Knopman, D, Fazekas, F, Wolf, P A, van der Lugt, A, Gudnason, V, Longstreth, J W T, Brown, M A, Bennett, D A, van Duijn, C M, Mosley, T H, Schmidt, R, Tzourio, C, Launer, L J, Arfan Ikram, M & Seshadri, S 2012, ' Common variants at 12q14 and 12q24 are associated with hippocampal volume ', Nature Genetics, vol. 44, no. 5, pp. 545-551 . https://doi.org/10.1038/ng.2237, Nature Genetics, 44(5), 545, Nature Genetics, 44, 5, pp. 545-51, Nature Genetics, 44(5), 545-551. Nature Publishing Group, Nature genetics, Nature genetics 44(5), 545-551 (2012). doi:10.1038/ng.2237, Nature Genetics, 44, 545-51
- Accession number :
- edsair.doi.dedup.....1360be8c75412b0bb2e5ba8b576b3b8f
- Full Text :
- https://doi.org/10.1038/ng.2237⟩