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Standardised exercise training is feasible, safe and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension - results from a large European multicentre randomised controlled trial
Standardised exercise training is feasible, safe and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension - results from a large European multicentre randomised controlled trial
- Source :
- Grünig, E, MacKenzie, A, Peacock, A J, Eichstaedt, C A, Benjamin, N, Nechwatal, R, Ulrich, S, Saxer, S, Bussotti, M, Sommaruga, M, Ghio, S, Gumbiene, L, Palevičiūtė, E, Jurevičienė, E, Cittadini, A, Stanziola, A A, Marra, A M, Kovacs, G, Olschewski, H, Barberà, J-A, Blanco, I, Spruit, M A, Franssen, F M E, Vonk Noordegraaf, A, Reis, A, Santos, M R, Viamonte, S G, Demeyer, H, Delcroix, M, Bossone, E & Johnson, M 2021, ' Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial ', European Heart Journal, vol. 42, no. 23, pp. 2284-2295 . https://doi.org/10.1093/eurheartj/ehaa696, European Heart Journal, 42(23), 2284-2295. Oxford University Press, EUROPEAN HEART JOURNAL
- Publication Year :
- 2020
- Publisher :
- European Respiratory Society, 2020.
-
Abstract
- Aims This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results For the first time a specialized PAH/CTEPH rehabilitation programme was implemented in 11 centres across 10 European countries. Out of 129 enrolled patients, 116 patients (58 vs. 58 randomized into a training or usual care control group) on disease-targeted medication completed the study [85 female; mean age 53.6 ± 12.5 years; mean pulmonary arterial pressure 46.6 ± 15.1 mmHg; World Health Organization (WHO) functional class II 53%, III 46%; PAH n = 98; CTEPH n = 18]. Patients of the training group performed a standardized in-hospital rehabilitation with mean duration of 25 days [95% confidence interval (CI) 17–33 days], which was continued at home. The primary endpoint, change of 6-min walking distance, significantly improved by 34.1 ± 8.3 m in the training compared with the control group (95% CI, 18–51 m; P Conclusion This is the first multicentre and so far the largest randomized, controlled study on feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH. Within this study, a standardized specialized training programme with in-hospital start was successfully established in 10 European countries.
- Subjects :
- Male
medicine.medical_treatment
030204 cardiovascular system & hematology
law.invention
0302 clinical medicine
Randomized controlled trial
QUALITY-OF-LIFE
law
Exercise programme
Medicine and Health Sciences
Clinical endpoint
Prospective Studies
Exercise Tolerance
Rehabilitation
Middle Aged
Europe
medicine.anatomical_structure
Female
Chronic thromboembolic pulmonary hypertension
Cardiology and Cardiovascular Medicine
WALK TEST
Adult
medicine.medical_specialty
Hypertension, Pulmonary
END-POINT
Pulmonary arterial pressure
Pulmonary hypertension
CAPACITY
03 medical and health sciences
Walking distance
Internal medicine
BENEFITS
medicine
Humans
Pulmonary rehabilitation
In patient
Exercise
Aged
Lung
Surrogate endpoint
business.industry
EFFICACY
medicine.disease
Confidence interval
030228 respiratory system
Chronic Disease
Usual care
Quality of Life
Physical therapy
business
Subjects
Details
- ISSN :
- 0195668X and 15229645
- Database :
- OpenAIRE
- Journal :
- Pulmonary hypertension
- Accession number :
- edsair.doi.dedup.....13683a0c179829c8c8e22c3ce6ac6105
- Full Text :
- https://doi.org/10.1183/13993003.congress-2020.3972