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Prevalence of obesity and obesity-associated muscle wasting in patients on peritoneal dialysis
- Publication Year :
- 2019
-
Abstract
- Background and aims: A progressive decrease in muscle mass until full-blown sarcopenia may occur in patients on peritoneal dialysis (PD) and worsen their life quality and expectancy. Here we investigate the prevalence of obesity and obesity-associated muscle wasting in PD patients. Patients and methods: The study design was observational, cross sectional. Body composition was assessed with BIA and BIVA in 88 PD patients (53.4 ± 13.1 years; 67% male). Patients with obesity and/or with reduced muscle mass were identified using FMI and SM/BW cutoff values, respectively. Inflammatory status was assessed by measuring CRP and fibrinogen blood levels. Results: A total of 44.3% of the patients showed a reduced muscle mass (37.5% moderate and 6.8% severe). The prevalence of obesity was 6.1%, 81.8%, and 100% in patients with normal, moderately, and severely reduced muscle mass, respectively (p < 0.05). Of the total, 15.2% of the patients with normal muscle mass, 18.4% of those with moderately reduced muscle mass, and 66.7% of those with severely reduced muscle mass had diabetes. The prevalence of severe muscle mass loss was higher in those with diabetes than in those without diabetes (22.2% vs. 2.8%, p < 0.05). Patients with obesity-associated muscle wasting showed higher fibrinogen (613.9 ± 155.1 vs. 512.9 ± 159.5 mg/dL, p < 0.05) and CPR (1.4 ± 1.3 vs. 0.6 ± 0.8 mg/dL, p < 0.05) blood concentrations than those with normal body composition. Conclusion: Obesity and diabetes were strongly associated with muscle mass loss in our PD patients. It remains to be established whether prevention of obesity with nutritional interventions can halt the occurrence of muscle mass loss in patients on PD.
- Subjects :
- Male
Sarcopenia
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Medicine (miscellaneous)
BIVA
030204 cardiovascular system & hematology
Gastroenterology
Muscle wasting
0302 clinical medicine
Risk Factors
Prevalence
Wasting
Inflammation Mediator
Nutrition and Dietetics
Diabetes Mellitu
Middle Aged
medicine.anatomical_structure
C-Reactive Protein
Italy
Body Composition
Female
medicine.symptom
Inflammation Mediators
Cardiology and Cardiovascular Medicine
Peritoneal Dialysis
Human
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Risk Assessment
Peritoneal dialysis
Peritoneal Dialysi
03 medical and health sciences
Diabetes mellitus
Internal medicine
BIA
medicine
Diabetes Mellitus
Humans
Obesity
Dialysis
Aged
Cross-Sectional Studie
business.industry
Risk Factor
Skeletal muscle
Fibrinogen
Biomarker
medicine.disease
Cross-Sectional Studies
Blood chemistry
Kidney Failure, Chronic
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....136b9cf462df3016c77f5e20267c7f62