Back to Search Start Over

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Authors :
Léo Piquet
Mathieu Blais
Maude Vaillancourt-Audet
Julie Fradette
Isabelle Laverdière
Stéphane Chabaud
Emil Grammond
François A. Auger
Stéphane Bolduc
Brice Magne
Vincent Roy
Lucie Germain
François Gros-Louis
Véronique J. Moulin
Solange Landreville
Source :
BioMed Research International, BioMed Research International, Vol 2020 (2020)
Publication Year :
2020
Publisher :
Hindawi, 2020.

Abstract

Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.

Details

Language :
English
ISSN :
23146141 and 23146133
Volume :
2020
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....136f2deb679e0c4578d752a2f92fc304