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Global Spread of the B5 Subgenotype EV-A71 and the Phylogeographical Analysis of Chinese Migration Events
- Source :
- Frontiers in Cellular and Infection Microbiology, Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
- Publication Year :
- 2020
-
Abstract
- The subgenotype B5 of EV-A71 is a widely circulating subgenotype that frequently spreads across the globe. Several outbreaks have occurred in nations, such as Malaysia, Thailand, Vietnam, and Japan. Appearing first in Taiwan, China, the subgenotype has been frequently reported in mainland of China even though no outbreaks have been reported so far. The current study reconstructed the migration of the B5 subgenotype of EV-A71 in China via phylogeographical analysis. Furthermore, we investigated its population dynamics in order to draw more credible inferences. Following a dataset cleanup of B5 subgenotype of EV-A71, we detected earlier B5 subgenotypes of EV-A71 sequences that had been circulating in Malaysia and Singapore since the year 2000, which was before the 2003 outbreak that occurred in Sarawak. The Bayesian inference indicated that the most recent common ancestor of B5 subgenotype EV-A71 appeared in September, 1994 (1994.75). With respect to the overall prevalence, geographical reconstruction revealed that the B5 subgenotype EV-A71 originated singly from single-source cluster and subsequently developed several active lineages. Based on a large amount of data that was accumulated, we conclude that the appearance of the B5 subgenotype of EV-A71 in mainland of China was mainly due to multiple migrations from different origins.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
China
030106 microbiology
Immunology
Population
lcsh:QR1-502
Taiwan
Disease cluster
migration
Microbiology
lcsh:Microbiology
03 medical and health sciences
Cellular and Infection Microbiology
Japan
Enterovirus Infections
Humans
education
Phylogeny
Original Research
education.field_of_study
Singapore
molecular evolution
Outbreak
Bayes Theorem
Enterovirus a71
Thailand
Enterovirus A, Human
030104 developmental biology
Infectious Diseases
Geography
enterovirus A71
Vietnam
Evolutionary biology
phylogeographical analysis
Mainland
Hand, Foot and Mouth Disease
B5 subgenotype
Subjects
Details
- ISSN :
- 22352988
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in cellular and infection microbiology
- Accession number :
- edsair.doi.dedup.....13706f4942b8371f8e4520c9d53d3b0b