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Effect of renal function on pemetrexed-induced haematotoxicity
- Source :
- Cancer Chemotherapy and Pharmacology
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Purpose Pemetrexed (PEM) is an anticancer agent used for the treatment of non-small cell lung cancer, malignant pleural mesothelioma and thymoma. Reportedly, PEM has higher efficacy and safety when used in combination with platinum-based agents. However, there are only few reports on the safety of PEM in patients with an eGFR of ≤45 mL/min. We examined the effect of renal function on the safety of regimens containing PEM. Methods We retrospectively reviewed 221 patients with lung cancer, malignant pleural mesothelioma or thymoma who received treatment with a PEM-containing regimen between 2009 and 2014. Subgroup analyses were performed on the basis of pre-treatment renal function: group A [creatinine clearance (CLcr)
- Subjects :
- Thrombocytopaenia
Male
Mesothelioma
0301 basic medicine
Oncology
Cancer Research
Lung Neoplasms
Malignant pleural mesothelioma
Kidney Function Tests
urologic and male genital diseases
Toxicology
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Non-small cell lung cancer
Risk Factors
Carcinoma, Non-Small-Cell Lung
Antineoplastic Combined Chemotherapy Protocols
Pharmacology (medical)
Incidence
Middle Aged
Pemetrexed
Creatinine
030220 oncology & carcinogenesis
Renal dysfunction
Original Article
Female
Glomerular Filtration Rate
medicine.drug
medicine.medical_specialty
Thymoma
Pleural Neoplasms
Renal function
03 medical and health sciences
Internal medicine
medicine
Humans
Risk factor
Lung cancer
Aged
Retrospective Studies
Pharmacology
business.industry
Mesothelioma, Malignant
medicine.disease
Thrombocytopenia
Regimen
030104 developmental biology
chemistry
Multivariate Analysis
business
Subjects
Details
- ISSN :
- 14320843 and 03445704
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Cancer Chemotherapy and Pharmacology
- Accession number :
- edsair.doi.dedup.....138d5e01fa5e613a6ee085c17d2e7218