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Conservative versus liberal oxygen therapy in relation to all-cause mortality among patients in the intensive care unit: a systematic review of randomized controlled trials with meta-analysis and trial sequential analysis
- Source :
- Medicina Intensiva (English Edition). 47:73-83
- Publication Year :
- 2023
- Publisher :
- Elsevier BV, 2023.
-
Abstract
- Objective To evaluate the benefits and harmful effects of conservative versus liberal oxygen therapy in patients admitted to the Intensive Care Unit (ICU). Design A systematic review and meta-analysis was carried out. Setting ICU. Participants Adult patients (aged 18 years or older) were randomized to either a lower oxygenation target strategy (conservative oxygen therapy) or a higher oxygenation target strategy (liberal oxygen therapy) in the ICU. Interventions Patients received different oxygenation target strategies. Results Ten studies involving 5429 adult patients admitted to the ICU were included in the meta-analysis. The pooled results showed no decreased all-cause mortality at 28 days (RR 0.90; 95%CI 0.75–1.09; p = 0.28), 90 days (RR 1.02; 95%CI 0.92–1.13; p = 0.71) or longest follow-up (RR 0.97; 95%CI 0.88–1.08; p = 0.63) among patients administered conservative oxygen therapy. Secondary outcomes were comparable between the two groups. The results of sensitivity analyses and subgroup analyses were consistent with the main analyses. Conclusion No beneficial or harmful effects of conservative oxygen therapy were found compared to liberal oxygen therapy in relation to all-cause mortality among adult patients in the ICU. Conservative oxygen therapy did not reduce all-cause mortality at 28 days, 90 days or longest follow-up. Other important clinical outcomes were also comparable between the two groups.
- Subjects :
- medicine.medical_specialty
Adult patients
business.industry
medicine.medical_treatment
Psychological intervention
Oxygenation
General Medicine
Critical Care and Intensive Care Medicine
Intensive care unit
law.invention
Randomized controlled trial
law
Meta-analysis
Oxygen therapy
Emergency medicine
Medicine
business
All cause mortality
Subjects
Details
- ISSN :
- 21735727
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Medicina Intensiva (English Edition)
- Accession number :
- edsair.doi.dedup.....1399442dec81ae0a0d3163259ebe97b2
- Full Text :
- https://doi.org/10.1016/j.medine.2021.08.015