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RESTING HEART RATE AND ARTERIAL STIFFNESS: A LONGITUDINAL PROSPECTIVE STUDY IN A POPULATION OF HYPERTENSIVE PATIENTS

Authors :
Maloberti, Alessandro
Fumagalli, Stefano
Garofani, Ilaria
Ghidini, Simone
Ruzzenenti, Giacomo
Bombelli, Michele
Fabbri, Saverio
Giannattasio, Cristina
Maloberti, A
Fumagalli, S
Garofani, I
Ghidini, S
Ruzzenenti, G
Bombelli, M
Fabbri, S
Giannattasio, C
Source :
Journal of Hypertension. 40:e132
Publication Year :
2022
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2022.

Abstract

Background The role of resting Heart Rate on the progression of arterial stiffness has not yet been extensively evaluated. The aim of this study is to investigate the relationship between resting HR and baseline arterial stiffness (evaluated by cfPWV) as well as its progression in a population of hypertensive patients over a 3.7 years follow-up period. Methods We enrolled 572 hypertensive outpatients 18–80 aged, followed by one hospital in Northern Italy. Anamnestic, clinical and laboratory data, BP and cfPWV were assessed at baseline and after a median follow-up time of 3.7±0.5 years Results At baseline the mean age was 53.9±12.7 years, SBP and DBP were 141.2±17.8 and 86.5±10.5 mmHg, HR was 65.6±10.9 bpm and PWV was 8.6±2.0 m/s. Despite an improvement in BP values (from 141.2/86.5 to 132.6/79.2 mmHg, p Conclusions in hypertensive patients there is a significant relationship between basal resting HR and basal PWV as well as between the increase of HR and the increase of PWV during the follow-up period. Beyond age and BP, resting HR must be considered as an independent determinant of arterial stiffness. This represents a possible mechanism through which HR contributes to the increase in CV risk. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Niguarda Hospital, Milan, Italy

Details

ISSN :
14735598 and 02636352
Volume :
40
Database :
OpenAIRE
Journal :
Journal of Hypertension
Accession number :
edsair.doi.dedup.....13a896dff8b18d04b045b2143aee1d75
Full Text :
https://doi.org/10.1097/01.hjh.0000836624.21744.7e