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The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- The rapid increase in use of electronic-cigarettes (e-cigarettes), especially among youth, raises the urgency for regulating bodies to make informed decisions, guidance, and policy on these products. This study evaluated cardiac function in an experimental model following exposure to e-cigarettes. We subjected C57BL/6 mice to e-cigarette vaping for 2-weeks, and cardiac function was assessed using echocardiography. Cardiac tissues were collected at the end of e-cigarette exposure for pathological analysis. The experimental data showed that e-cigarette vaping (3 h/day for 14 days) had no significant effect on cardiac contractility as measured by ejection fraction. However, it significantly increased angiogenesis in mouse heart tissue. We found that e-cigarette exposure increased the endothelial cell marker CD31 and CD34 to approximately 2 fold (p
- Subjects :
- 0301 basic medicine
Cardiac function curve
CD31
Male
medicine.medical_specialty
Angiogenesis
lcsh:Medicine
Antigens, CD34
Electronic Nicotine Delivery Systems
Weight Gain
Article
Neovascularization
Contractility
03 medical and health sciences
Mice
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
lcsh:Science
Multidisciplinary
Ejection fraction
Neovascularization, Pathologic
business.industry
Vaping
lcsh:R
Myocardial Contraction
3. Good health
Endothelial stem cell
Platelet Endothelial Cell Adhesion Molecule-1
Disease Models, Animal
030104 developmental biology
Endocrinology
Echocardiography
Heart Function Tests
Female
lcsh:Q
medicine.symptom
business
Weight gain
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....13b7958ad949a02af18945c7b7180517