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Prospective study of natural killer cell phenotype in recurrent hepatitis C virus infection following liver transplantation
- Source :
- Journal of Hepatology. 50:314-322
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Graft re-infection invariably occurs after liver transplantation (OLT) for chronic hepatitis C and disease progression is unpredictable. We prospectively examined peripheral blood mononuclear cells (PBMC) subsets and natural killer (NK) cell receptors (NKRs) in patients with recurrent hepatitis C post-OLT.PBMC were obtained at baseline and at different time points after OLT. NKRs were identified using monoclonal antibodies by flow cytometry.The proportions of NK, natural T (NT), total and gammadelta T cells were significantly reduced (p0.01) 7 days post-transplant, probably as a result of graft repopulation. NKG2D+ NK cells were significantly higher compared with healthy controls (p0.01), declined post-OLT and subsequently returned to baseline values. This, together with a progressive increase in the proportion of CD94/NKG2C+ NK cells over time (por = 0.01), appeared to be related to hepatitis C recurrence. There was a statistically significant correlation between expression of the natural cytotoxicity receptors (NCRs) and ALT (p0.05), supporting the hypothesis that NK cells participate in the necroinflammatory process.The data are compatible with homing of immune cells to the liver allograft after surgery, most of which return to pre-OLT levels. HCV recurrence may cause variations in selected NKRs expression akin to other viral infections.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_treatment
Hepatitis C virus
Biology
Liver transplantation
medicine.disease_cause
Peripheral blood mononuclear cell
Immunophenotyping
Natural killer cell
Immune system
Primary biliary cirrhosis
Recurrence
medicine
Humans
Prospective Studies
Aged
Hepatology
Hepatitis C
Middle Aged
medicine.disease
CD56 Antigen
Liver Transplantation
Killer Cells, Natural
surgical procedures, operative
medicine.anatomical_structure
NK Cell Lectin-Like Receptor Subfamily K
Immunology
Female
Subjects
Details
- ISSN :
- 01688278
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....13bb1ef3d8ed0c718b56f830ac333dea