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Predictive Value of Stemness Factor Sox2 in Gastric Cancer Is Associated with Tumor Location and Stage
- Source :
- PLoS ONE, Vol 12, Iss 1, p e0169124 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Cancer stem cells (CSCs) are thought to be the "root" of cancer. Although stemness-related factors ALDH1A1 and Sox2 have been used as markers to identify gastric CSCs, the expression pattern and significance of these factors in gastric cancer have not been sufficiently demonstrated. In this study, the expressions of ALDH1A1 and Sox2 were detected by immunohistochemistry in 122 gastric cancer specimens. And the correlation between Sox2 or ALDH1A1 expression and clinicopathological parameters and overall survival data were analyzed. The positive rate of ALDH1A1 expression was 60%, but there was no significant difference between survival rates of ALDH1A1-positive and ALDH1A1-negative patients. Sox2 was expressed in 42% of specimens and was associated with poor prognosis of patients (P = 0.015). Stratified analysis showed that Sox2 expression correlated with shorter lifespan only in patients with cardiac gastric cancers (P = 0.002) or stage I or II gastric cancers (P = 0.002); but not in patients with non-cardiac cancers (P = 0.556) or stage III or IV gastric cancers (P = 0.121). Analysis on a database cohort validated the correlation between Sox2 expression and poor prognosis in stage II cancer. Also, expression of Sox2 was associated with lymphnode metastasis in patients with cardiac gastric cancer (P = 0.037). A multivariate analysis revealed that Sox2 was an independent prognostic factor in cardiac gastric cancer. Our results indicate that predictive value of Sox2 in gastric cancer is associated with cardiac cancer location and with early cancer stages (I and II).
- Subjects :
- Male
0301 basic medicine
Oncology
Carcinogenesis
Gene Expression
lcsh:Medicine
Metastasis
Cohort Studies
Mathematical and Statistical Techniques
0302 clinical medicine
Animal Cells
Cancer Stem Cells
Basic Cancer Research
Medicine and Health Sciences
Medicine
Stage (cooking)
lcsh:Science
Aged, 80 and over
Multidisciplinary
biology
Stem Cells
Middle Aged
Prognosis
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Treatment Outcome
Lymphatic Metastasis
030220 oncology & carcinogenesis
Predictive value of tests
Physical Sciences
Disease Progression
Female
Cellular Types
Anatomy
Statistics (Mathematics)
Research Article
Adult
medicine.medical_specialty
Research and Analysis Methods
Aldehyde Dehydrogenase 1 Family
Lymphatic System
03 medical and health sciences
SOX2
Predictive Value of Tests
Stomach Neoplasms
Diagnostic Medicine
Cancer stem cell
Internal medicine
Gastrointestinal Tumors
Genetics
Humans
Statistical Methods
Aged
Neoplasm Staging
business.industry
Gene Expression Profiling
SOXB1 Transcription Factors
lcsh:R
Retinal Dehydrogenase
Cancers and Neoplasms
Biology and Life Sciences
Cancer
Cell Biology
Aldehyde Dehydrogenase
medicine.disease
Gastrointestinal Tract
ALDH1A1
Gastric Cancer
030104 developmental biology
Multivariate Analysis
biology.protein
lcsh:Q
Lymph Nodes
business
Digestive System
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....13c439c6fcba146e9e77d8672a067865