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Clinical Research on Alzheimer’s Disease: Progress and Perspectives
- Publication Year :
- 2018
- Publisher :
- Springer Singapore, 2018.
-
Abstract
- Alzheimer’s disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Neurology
Biomedical Research
Physiology
Amyloid beta
Disease
Review
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
medicine
Global health
Dementia
Animals
Humans
Intensive care medicine
biology
business.industry
General Neuroscience
General Medicine
medicine.disease
Magnetic Resonance Imaging
Biomarker (cell)
Clinical trial
030104 developmental biology
Clinical research
biology.protein
Disease Progression
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....13c545904407bd4a2ea7ce3a90e7d272