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Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host
- Source :
- International journal of medical microbiology : IJMM. 292(7-8)
- Publication Year :
- 2003
-
Abstract
- In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 A/B, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.
- Subjects :
- Microbiology (medical)
Peptic Ulcer
Spirillaceae
Disease
digestive system
Microbiology
Helicobacter Infections
Bacterial Proteins
Germany
CagA
Humans
Genetic Predisposition to Disease
Allele
Alleles
Antigens, Bacterial
Polymorphism, Genetic
biology
Helicobacter pylori
T-cell receptor
General Medicine
HLA-DR Antigens
bacterial infections and mycoses
biology.organism_classification
Virology
Antibodies, Bacterial
digestive system diseases
Infectious Diseases
Cohort
Immunology
biology.protein
Antibody
HLA-DRB1 Chains
Subjects
Details
- ISSN :
- 14384221
- Volume :
- 292
- Issue :
- 7-8
- Database :
- OpenAIRE
- Journal :
- International journal of medical microbiology : IJMM
- Accession number :
- edsair.doi.dedup.....13cb3abc464042cef08d66b2735650c2