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Onydecalins, Fungal Polyketides with Anti-Histoplasma and Anti-TRP Activity
- Publication Year :
- 2018
-
Abstract
- We report an unusual 3-substituted pyridine polyketide, onydecalin A (1), which was obtained along with 2 as a major constituent from the fungus Aioliomyces pyridodomos (Order: Onygenales) following a two-month fermentation. Feeding studies demonstrated that the pyridine subunit originates via an unprecedented biosynthetic process in comparison to other polyketide-linked pyridines or derivatives such as pyridones. The slow growth of the fungus led us to perform a one-year fermentation, leading to production of compounds 2-4 as the major constituents. These compounds showed modest but selective inhibition against a variety of transient receptor potential channels, as well as against the human pathogenic fungus, Histoplasma capsulatum.
- Subjects :
- 0301 basic medicine
Protein subunit
Histoplasma
Pharmaceutical Science
Fungus
Article
Analytical Chemistry
03 medical and health sciences
Polyketide
Transient Receptor Potential Channels
Ascomycota
Drug Discovery
Humans
Histoplasmosis
Pharmacology
Biological Products
biology
Molecular Structure
Chemistry
Organic Chemistry
Onygenales
Pathogenic fungus
biology.organism_classification
030104 developmental biology
Complementary and alternative medicine
Biochemistry
Biosynthetic process
Polyketides
Fermentation
Molecular Medicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....13d2dfba0df2fd44c789b62bb824c235