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An extremely facile synthesis of furans, pyrroles, and thiophenes by the dehydrative cyclization of propargyl alcohols

Authors :
Chuan‐Ying Li
Jeremy Malinge
Aaron Aponick
Emerson Finco Marques
Source :
Organic letters. 11(20)
Publication Year :
2009

Abstract

Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargylic alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles in minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.

Details

ISSN :
15237052
Volume :
11
Issue :
20
Database :
OpenAIRE
Journal :
Organic letters
Accession number :
edsair.doi.dedup.....13e4c78dd8054d759dac448ef09c2dff