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Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder
- Source :
- Journal of Psychiatric Research, 125, 66-74. Elsevier B.V., Journal of Psychiatric Research, 125, 66-74. Elsevier, Journal of psychiatric research, 125, 66-74. Elsevier Limited
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- BACKGROUND: Suicide, psychotic features and gender influence the epidemiology and clinical prognosis of bipolar disorder (BD). Differences in glial function between the genders might contribute to these clinical variables. Here we studied expression of glial genes in human post-mortem prefrontal cortex of BD and control subjects in relation to suicide, psychotic features and sex.METHODS: Real time PCR was used to detect transcriptional alterations of 16 glia-related genes in two brain areas, the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC), from 30 patients with BD subdivided by suicide and psychotic features, and from 34 well-matched control cases.RESULTS: We found no evidence of immune activation in BD. Instead, we found three microglial genes to be downregulated in the DLPFC of non-suicidal individuals with BD, i.e. CD68, triggering receptor expressed on myeloid cells 2 (TREM2) and purinergic receptor 12 (P2RY12). A remarkable sex difference was observed in the DLPFC of patients with BD: 14 glia-related genes were expressed at significantly higher levels in males, including all three glial cell types. A subset analysis showed that the sex differences were closely associated with the presence of psychotic features.CONCLUSIONS: No evidence of immune activation was found in these two brain regions in BD. The sex-specific differences in glial gene expression in BD, found particularly in patients with psychotic features, may be associated with the potential co-existence of mania and psychotic features and could potentially contribute to the gender-biased characteristics in BD.
- Subjects :
- Male
Subset Analysis
Cell type
medicine.medical_specialty
Bipolar Disorder
Gene Expression
Prefrontal Cortex
Psychotic features
03 medical and health sciences
0302 clinical medicine
Glia
Internal medicine
Sex differences
medicine
Humans
Bipolar disorder
Receptors, Immunologic
Prefrontal cortex
Biological Psychiatry
Anterior cingulate cortex
Sex Characteristics
Membrane Glycoproteins
business.industry
TREM2
medicine.disease
030227 psychiatry
Dorsolateral prefrontal cortex
Suicide
Psychiatry and Mental health
medicine.anatomical_structure
Endocrinology
Female
medicine.symptom
business
Neuroglia
Mania
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 18791379 and 00223956
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatric Research
- Accession number :
- edsair.doi.dedup.....13ea14baa0662262251f236ccd9fcb1d