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High-performance liquid chromatographic determination of ethmozin in plasma
- Source :
- Journal of pharmaceutical sciences. 70(4)
- Publication Year :
- 1981
-
Abstract
- A sensitive, specific high-performance liquid chromatographic procedure was developed for the determination of plasma ethmozin levels. Basic plasma samples were partitioned with methylene chloride. The organic extract was washed with water and then evaporated to dryness under reduced pressure. The residue was redissolved in 0.2 ml of the mobile phase, consisting of hexane-tetrahydrofuran-methanol-water (66:27:6,30:0.7 v/v), and then chromatographed on a microporous silica column. With a variable-wavelength UV detector set at 268 nm, 10 ng of ethmozin/ml of plasma was measured. The utility of the method for human pharmacokinetic studies was demonstrated.
- Subjects :
- Male
Chromatography
Plasma samples
Uv detector
Morpholines
Analytical chemistry
Pharmaceutical Science
Silica column
Microporous material
Plasma
Chloride
Moricizine
chemistry.chemical_compound
Kinetics
chemistry
Phenothiazines
medicine
Humans
Methylene
Chromatography, High Pressure Liquid
medicine.drug
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 70
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....13ea69a462015b45538348d2b3ae8b05