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Ischemia-related changes in circulating stem and progenitor cells and associated clinical characteristics in peripheral artery disease
- Source :
- Vascular medicine (London, England), vol 20, iss 6
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- The extent and clinical significance of stem and progenitor cell (SPC) increases in response to lower-extremity ischemia in people with peripheral artery disease (PAD) are unclear. We compared changes in SPC levels immediately following a treadmill exercise test between individuals with and without PAD. Among participants with PAD, we determined whether more severe PAD was associated with greater increases in SPCs following treadmill exercise-induced lower-extremity ischemia. We measured SPC levels in 25 participants with PAD and 20 without PAD before and immediately after a treadmill exercise test. Participants with PAD, compared to participants without PAD, had greater increases in CD34+CD45dim (+0.08±0.03 vs −0.06±0.04, p=0.008), CD34+CD45dimCD133+ (+0.08±0.05 vs −0.08±0.04, p=0.014), CD34+CD45dimCD31+ (+0.10±0.03 vs −0.07±0.04, p=0.002), and CD34+CD45dimALDH+ SPCs (+0.18±0.07 vs −0.05±0.08, p=0.054) measured as a percentage of all white blood cells. Among participants with PAD, those with any increases in the percent of SPCs immediately after the treadmill exercise test compared to those with no change or a decrease in SPCs had lower baseline ankle–brachial index values (0.65±0.17 vs 0.90±0.19, p=0.004) and shorter treadmill times to onset of ischemic leg symptoms (2.17±1.54 vs 5.25±3.72 minutes, p=0.012). In conclusion, treadmill exercise-induced lower-extremity ischemia is associated with acute increases in circulating SPCs among people with PAD. More severe PAD is associated with a higher prevalence of SPC increases in response to lower-extremity ischemia. Further prospective study is needed to establish the prognostic significance of ischemia-related increases in SPCs among patients with PAD.
- Subjects :
- Male
CD34
Cell Count
Regenerative Medicine
Cardiovascular
Severity of Illness Index
treadmill exercise
Stem Cell Research - Nonembryonic - Human
Ischemia
Treadmill
Prospective cohort study
Stem Cells
Middle Aged
Flow Cytometry
CD
Phenotype
Lower Extremity
Cardiology
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Clinical Sciences
ischemia
peripheral artery disease
Article
Peripheral Arterial Disease
Clinical Research
Antigens, CD
Internal medicine
Severity of illness
medicine
Humans
Ankle Brachial Index
Clinical significance
Antigens
Progenitor cell
Aged
business.industry
Case-control study
Stem Cell Research
medicine.disease
stem and progenitor cells
Surgery
Cross-Sectional Studies
Cardiovascular System & Hematology
Case-Control Studies
Exercise Test
business
Biomarkers
Subjects
Details
- ISSN :
- 14770377 and 1358863X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Vascular Medicine
- Accession number :
- edsair.doi.dedup.....13f1e225c10c30f94bbcbde4f9b267ca