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Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population
- Source :
- The journals of gerontology. Series A, Biological sciences and medical sciences. 66(11)
- Publication Year :
- 2011
-
Abstract
- Cytochrome P450 enzymes, especially the CYP2C subfamily, are involved in the generation of reactive oxygen species and are regarded as susceptibility factors for age-related diseases. Furthermore, the CYP2C-encoding genes are known to be highly polymorphic, with a number of variants leading to changes in enzyme activity. These observations prompted us to investigate whether allelic variation in the CYP2C-encoding genes was associated with human longevity. In a comprehensive haplotype tagging approach, we genotyped 56 single nucleotide polymorphisms located in the CYP2C gene family (CYP2C8, CYP2C9, CYP2C18, and CYP2C19) in our extensive collection of 1,384 long-lived individuals (centenarians and nonagenarians) and 945 younger controls. None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level. These results suggest that there is no notable influence of sequence variation in the CYP2C genes on longevity in the examined German population.
- Subjects :
- Male
Aging
Subfamily
media_common.quotation_subject
Longevity
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Cytochrome P-450 CYP2C8
Cytochrome P-450 Enzyme System
Germany
Genetic variation
Genotype
Humans
Genetic Predisposition to Disease
Allele
Gene
Genetic Association Studies
media_common
Cytochrome P-450 CYP2C9
Genetics
Aged, 80 and over
Haplotype
Genetic Variation
Cytochrome P-450 CYP2C19
Female
Aryl Hydrocarbon Hydroxylases
Geriatrics and Gerontology
Subjects
Details
- ISSN :
- 1758535X
- Volume :
- 66
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Accession number :
- edsair.doi.dedup.....140fb3fc99e88d89c5353add34ef748e