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Elevated IgG4 serum levels in patients with cystic fibrosis
- Source :
- PLoS ONE, Vol 12, Iss 9, p e0181888 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Objective Serum immunoglobulin (Ig) G4 elevation has been associated with several pathological conditions other than IgG4-related disease (IgG4-RD). In cystic fibrosis (CF), an elevation of specific IgG4 has been associated with colonization and infection by Pseudomonas aeruginosa. IgG4 elevation may be a marker of chronic infection or inflammatory stimulation. The aim of this study was to explore the prevalence of elevated IgG4 levels in CF and its correlation with the major clinical and microbiological features found in CF patients. Methods In a cross-sectional study, we analyzed data from a large cohort of adult CF patients attending the CF center of Lyon University Hospital. An elevated IgG4 level was defined as being above the cut-off value of 135 mg/dL. Results One hundred and sixty-five CF patients were analyzed. An IgG4 elevation was detected in 43 patients (26%). Compared with the control group (≤ 135 mg/dL), high IgG4 patients exhibited a greater prevalence of Staphylococcus aureus colonization and higher IgG, IgG1, IgG2 and IgE levels. No significant differences were observed in terms of pulmonary function, colonization with Pseudomonas aeruginosa, or the annual rate of bronchial exacerbations. Conclusion An elevated IgG4 serum level was frequently detected in adult CF patients and did not appear to be associated with poor lung function. We suggest that IgG4 elevation is a marker of the activation of tolerance. Its clinical significance remains to be demonstrated.
- Subjects :
- Male
0301 basic medicine
Cystic Fibrosis
Pulmonology
Physiology
Staphylococcus
Pulmonary Function
lcsh:Medicine
Pathology and Laboratory Medicine
Immunoglobulin E
medicine.disease_cause
Biochemistry
Gastroenterology
Cystic fibrosis
Plasma Cell Disorders
Immunoglobulin G
Pulmonary function testing
Cohort Studies
0302 clinical medicine
Immune Physiology
Hypergammaglobulinemia
Medicine and Health Sciences
Medicine
Staphylococcus Aureus
lcsh:Science
Immune Response
Immune System Proteins
Multidisciplinary
integumentary system
biology
Pseudomonas Aeruginosa
Hematology
Staphylococcal Infections
Antibodies, Bacterial
Bacterial Pathogens
Genetic Diseases
Medical Microbiology
Female
Pathogens
Research Article
Adult
medicine.medical_specialty
Immunology
Staphylococcal infections
Microbiology
Antibodies
03 medical and health sciences
Signs and Symptoms
Autosomal Recessive Diseases
Diagnostic Medicine
Pseudomonas
Internal medicine
parasitic diseases
Adults
Humans
Pseudomonas Infections
Clinical significance
Microbial Pathogens
Clinical Genetics
Inflammation
Bacteria
business.industry
Pseudomonas aeruginosa
lcsh:R
fungi
Organisms
Biology and Life Sciences
Proteins
medicine.disease
Fibrosis
030104 developmental biology
030228 respiratory system
Age Groups
People and Places
biology.protein
Population Groupings
lcsh:Q
business
Biomarkers
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....1418d822b37f27f9ef8133f1cf6f9bbb