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Reproductive and menstrual factors for papillary thyroid cancer risk: A case-control study in Chinese women
- Source :
- Cancer Epidemiology. 73:101964
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Thyroid cancer (TC) is threefold more common in women than men. Reproductive and menstrual factors may be related to the onset of papillary thyroid cancer (PTC). This study aims to determine the association of reproductive and menstrual factors with PTC in Chinese females.A total of 335 histologically confirmed cases of PTC were recruited in this case-control study. The controls were matched for age with a deviation of ± 2 years, which conducted from September 2016 to February 2019. Logistic regression models were applied to identify the association of reproductive and menstrual factors with PTC.After adjustment by some variables, early menarche age (OR ≤ 13 years vs. 13years = 2.40, 95 % CI 1.12-5.13) and shorter lifetime breastfeeding (OR6 months vs. ≥ 6 months = 1.99, 95 % CI 1.11-3.55) significantly increased the risk of PTC, whereas younger age at first pregnancy had a protective effect against PTC (OR ≤ 24years vs. 24 years = 0.66, 95 % CI 0.44-0.98). There was a positive correlation between premenopausal and PTC in the lower age group (OREarly menarche age, abortion, shorter breastfeeding duration and premenopausal may be related to the occurrence of PTC. Early age at first pregnancy and larger number of full-time pregnancies were possible to decrease the risk of PTC.
- Subjects :
- China
Cancer Research
medicine.medical_specialty
Adolescent
endocrine system diseases
Epidemiology
Breastfeeding
Abortion
Logistic regression
Papillary thyroid cancer
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
medicine
Humans
Thyroid Neoplasms
030212 general & internal medicine
Reproductive History
Thyroid cancer
Menarche
Obstetrics
business.industry
Case-control study
First pregnancy
medicine.disease
Menopause
Oncology
Thyroid Cancer, Papillary
Case-Control Studies
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 18777821
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology
- Accession number :
- edsair.doi.dedup.....143d7fa2d3581b2637f89b0fea5665c3