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The role of lamin A/C in mesenchymal stem cell differentiation
- Source :
- Journal of physiology and biochemistry. 75(1)
- Publication Year :
- 2017
-
Abstract
- Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.
- Subjects :
- 0301 basic medicine
congenital, hereditary, and neonatal diseases and abnormalities
Serum Response Factor
animal structures
Physiology
Receptors, Retinoic Acid
030209 endocrinology & metabolism
Tretinoin
Biology
Biochemistry
Mechanotransduction, Cellular
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Osteogenesis
medicine
Extracellular
Adipocytes
Humans
Adaptor Proteins, Signal Transducing
Cell Nucleus
Adipogenesis
Osteoblasts
integumentary system
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
YAP-Signaling Proteins
General Medicine
Lamin Type A
Phosphoproteins
Cell biology
Cell nucleus
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
embryonic structures
Trans-Activators
Osteoporosis
Mesenchymal stem cell differentiation
Lamin
Intracellular
Acyltransferases
Transcription Factors
Subjects
Details
- ISSN :
- 18778755
- Volume :
- 75
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of physiology and biochemistry
- Accession number :
- edsair.doi.dedup.....1442b310e660d070cfe5520be0cea24b