Serum Concentrations of Markers of TNFα and Fas-Mediated Pathways and Renal Function in Nonproteinuric Patients with Type 1 Diabetes

Authors :: Linda H. Ficociello
James H. Warram
Monika A. Niewczas
Andrzej S. Krolewski
Bijan Roshan
William F. Walker
Amanda C. Johnson
Elizabeth T. Rosolowsky
Source :: Clinical Journal of the American Society of Nephrology. 4:62-70
Publication Year :: 2009
Publisher :: Ovid Technologies (Wolters Kluwer Health), 2009.
Abstract: Background and objectives: The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria. Design, setting, participants, & measurements: The study group (the 2nd Joslin Kidney Study) comprised patients with T1DM and normoalbuminuria (NA) (n = 363) or microalbuminuria (MA) (n = 304). Impaired renal function (cC-GFR

Subjects :: Male
Epidemiology
Apoptosis
Kidney
urologic and male genital diseases
Critical Care and Intensive Care Medicine
Fas ligand
Diabetic Nephropathies
reproductive and urinary physiology
Chemokine CCL2
Proteinuria
biology
Middle Aged
Intercellular Adhesion Molecule-1
female genital diseases and pregnancy complications
C-Reactive Protein
medicine.anatomical_structure
Receptors, Tumor Necrosis Factor, Type I
Nephrology
Female
medicine.symptom
Glomerular Filtration Rate
Signal Transduction
Adult
medicine.medical_specialty
Fas Ligand Protein
Vascular Cell Adhesion Molecule-1
Renal function
Internal medicine
medicine
Albuminuria
Humans
Receptors, Tumor Necrosis Factor, Type II
fas Receptor
Cystatin C
Interleukin 6
Transplantation
urogenital system
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Interleukin-8
medicine.disease
Chemokine CXCL10
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Endocrinology
biology.protein
Microalbuminuria
business
Biomarkers
Diabetes and the Kidney

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