Back to Search
Start Over
Secretion and extracellular space travel of Wnt proteins
- Source :
- Current Opinion in Genetics & Development. 23:385-390
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Wnt signaling pathways control many processes during development, stem cell maintenance and homeostasis, and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Wnts are hydrophobic proteins, however, quite paradoxically, they can travel over distances to induce cell-type specific responses. While there has been an initial focus on elucidating the intracellular signaling cascade, discoveries in the past few years have shed light on a highly complex, and regulated secretory process that guides Wnt proteins through the exocytic pathway. Wnt proteins are at least in portion packaged onto extracellular carriers such as exosomes. Similar to dysregulation of components in the Wnt receiving cell, failure to regulate Wnt secretion has been linked to cancer. Here, we review recent discoveries on factors and processes implicated in Wnt secretion.
- Subjects :
- Neurodegeneration
Wnt signaling pathway
Gene Expression Regulation, Developmental
LRP6
Cell Differentiation
LRP5
Biology
Endoplasmic Reticulum
Exosomes
medicine.disease
Microvesicles
Cell biology
Wnt Proteins
Genetics
Extracellular
medicine
Animals
Humans
Secretion
Stem cell
Extracellular Space
Hydrophobic and Hydrophilic Interactions
Wnt Signaling Pathway
Developmental Biology
Subjects
Details
- ISSN :
- 0959437X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Genetics & Development
- Accession number :
- edsair.doi.dedup.....148c3da8cf96359fd09ef95d603793fc