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Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022), Nature Communications
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.<br />Ambient temperature significantly affects embryogenesis, but adaptive molecular mechanisms that respond to temperature remain unclear. Here, the authors identified species-specific thermal sensitivity of Notch signaling in developing amniote brains.
- Subjects :
- Science
Embryonic Development
General Physics and Astronomy
Developmental neurogenesis
Neocortex
Chick Embryo
Article
General Biochemistry, Genetics and Molecular Biology
Body Temperature
Mice
Species Specificity
Animals
Protein Isoforms
Receptor, Notch1
Neurons
Mice, Inbred ICR
Multidisciplinary
Phosphatidylethanolamines
Cell Membrane
Temperature
Gene Expression Regulation, Developmental
Development of the nervous system
General Chemistry
Embryo, Mammalian
Turtles
Transcription Factor HES-1
Evolutionary developmental biology
Chickens
Jagged-1 Protein
Cell signalling
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....14b4fe07169a2604bf6d7cdb37d5a916