Back to Search
Start Over
Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males
- Source :
- The journal of physiological sciences : JPS. 64(5)
- Publication Year :
- 2013
-
Abstract
- The aim of the present study was to investigate the effect of acute aerobic exercise on the expression of PGC-1α transcript variants in human skeletal muscle. Seven endurance-trained athletes performed a 90-min cycling test (62% of VO2max). At resting state, the levels of N-truncated (NT)-PGC-1α and PGC-1α exon 1a-derived transcripts were significantly higher (20-fold; P0.05) than those of PGC-1α exon 1b- and 1c-derived transcripts. Acute exercise did not change the PGC-1α exon 1a-derived expression level, but it did increase the expression level of NT-PGC-1α mRNAs 6-fold, and the expression levels of PGC-1α exon 1b- and 1c-derived mRNAs200-fold (P0.05). We conclude that NT-PGC-1α transcript expression in resting muscle and after acute moderate-intensity exercise constituted a significant share of total PGC-1α expression. The exercise led to a higher level of PGC-1α expression from alternative promoters (exon 1b- and 1c-derived mRNA) than from the canonical proximal promoter (exon 1a-derived mRNA).
- Subjects :
- Male
medicine.medical_specialty
Physiology
Peroxisome proliferator-activated receptor
Biology
Exon
Internal medicine
Coactivator
Gene expression
medicine
Aerobic exercise
Humans
Protein Isoforms
RNA, Messenger
Muscle, Skeletal
Exercise
chemistry.chemical_classification
Messenger RNA
Skeletal muscle
Promoter
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Endocrinology
medicine.anatomical_structure
chemistry
Physical Endurance
Transcription Factors
Subjects
Details
- ISSN :
- 18806562
- Volume :
- 64
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The journal of physiological sciences : JPS
- Accession number :
- edsair.doi.dedup.....14b58f4f11a349a32a8405c97467a764