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Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia
- Source :
- Archives of Medical Science : AMS
- Publication Year :
- 2017
- Publisher :
- Termedia Publishing House, 2017.
-
Abstract
- Introduction The effects of statins on lipoprotein-associated phospholipase A2 (Lp-PLA2) are controversial, and the present study aimed to investigate whether atorvastatin could reduce Lp-PLA2 in rats with dyslipidemia. Material and methods A high-fat and high-cholesterol diet was prescribed to produce a dyslipidemia model. Thereafter, low-dose atorvastatin (5 mg/kg/day), high-dose atorvastatin (20 mg/kg/day) or saline (without-treatment group) was prescribed for 14 days. At 6 weeks after dyslipidemia model establishment and 14 days of atorvastatin treatment, fasting venous blood was drawn for biochemical analysis. Between-group differences and Pearson correlation analysis were conducted. Results Compared to the normal-control group, fasting plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were significantly increased in dyslipidemia groups, while plasma nitric oxide (NO) levels were significantly decreased with attendant elevation of plasma C-reactive protein (CRP) and rho-associated kinase 1 (ROCK1) levels (p < 0.05). At 14 days of atorvastatin treatment, compared to the without-treatment group, plasma levels of TC and LDL-C in the high-dose group were significantly reduced (p < 0.05); and compared to low-dose and without-treatment groups, NO up-regulation (1.8 ±1.1 μmol/l), and CRP (-0.8 ±0.4 ng/ml), ROCK1 (-124 ±65 mmol/l) and Lp-PLA2 (-3.8 ±1.2 ng/ml) reduction were more significant in the high-dose group (p < 0.05). Pearson correlation analysis showed that TC (r = 0.365), LDL-C (r = 0.472), CRP (r = 0.501) and ROCK1 (r = 0.675) were positively correlated with Lp-PLA2, while NO (r = -0.378) and atorvastatin (r = -0.511) were negatively correlated with Lp-PLA2. Conclusions Atorvastatin treatment is beneficial for reducing the Lp-PLA2 level in rats with dyslipidemia, which may be related to reduced ROCK1 expression in a dose-dependent manner.
- Subjects :
- medicine.medical_specialty
Experimental Research
medicine.medical_treatment
Atorvastatin
030204 cardiovascular system & hematology
endothelial dysfunction
Nitric oxide
statins
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
030212 general & internal medicine
Endothelial dysfunction
Saline
Potential mechanism
lipoprotein-associated phospholipase A2
business.industry
Lipoprotein-associated phospholipase A2
dyslipidemia
General Medicine
Venous blood
medicine.disease
Endocrinology
chemistry
lipids (amino acids, peptides, and proteins)
business
Dyslipidemia
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 18969151 and 17341922
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Archives of Medical Science : AMS
- Accession number :
- edsair.doi.dedup.....14b591c89428d4298d2c4820eecab5fa