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Erythropoietin enhances whole body lipid oxidation during prolonged exercise in humans
- Source :
- Journal of Physiology and Biochemistry, Journal of Physiology and Biochemistry, 2015, 71 (1), pp.9-16. ⟨10.1007/s13105-014-0374-8⟩, Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2015, 71 (1), pp.9-16. ⟨10.1007/s13105-014-0374-8⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- Animal studies have suggested that erythropoietin, besides its well-known hematopoietic effects, can modulate metabolism and prevent fat accumulation. We investigated the effects of repeated injections of recombinant human erythropoietin (EPO) on the balance of substrate oxidation during aerobic exercise in humans. Twelve healthy aerobically trained males received subcutaneously either moderate dose of EPO (50 U/kg, EPO) or saline injections (NaCl 0.9 %, control) three times a week for 4 weeks. Body weight, % fat, maximal aerobic capacity, and substrate utilization during exercise were assessed before and after treatment, while hemoglobin and hematocrit were monitored regularly during the treatment. Carbohydrate and fat oxidation were evaluated via indirect calorimetry, during a submaximal exercise performed at 75 % of the participants’ maximal aerobic capacity ( $$ \overset{\cdotp }{V}{O}_{2 \max } $$ ) for 60 min. Results showed that 4 weeks of EPO treatment significantly enhanced fat oxidation (+56 % in EPO versus −9 % in control) during exercise, independent of its effects on hematological parameters or $$ \overset{\cdotp }{V}{O}_{2 \max } $$ . This study shows that EPO can modulate substrate utilization during exercise, leading to enhanced fat utilization and lower use of carbohydrates. This opens new research directions exploring whether systemic EPO levels, in physiological conditions, participate to the modulation of fat oxidation.
- Subjects :
- medicine.medical_specialty
Physiology
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
medicine.medical_treatment
030209 endocrinology & metabolism
Hematocrit
Biochemistry
03 medical and health sciences
0302 clinical medicine
Lipid oxidation
Internal medicine
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Humans
Aerobic exercise
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Erythropoietin
Exercise
Saline
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
medicine.diagnostic_test
business.industry
VO2 max
030229 sport sciences
General Medicine
Carbohydrate
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Lipid Metabolism
Recombinant Proteins
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Endocrinology
Hemoglobin
business
Oxidation-Reduction
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 11387548
- Database :
- OpenAIRE
- Journal :
- Journal of Physiology and Biochemistry, Journal of Physiology and Biochemistry, 2015, 71 (1), pp.9-16. ⟨10.1007/s13105-014-0374-8⟩, Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2015, 71 (1), pp.9-16. ⟨10.1007/s13105-014-0374-8⟩
- Accession number :
- edsair.doi.dedup.....14dd8abf865cfd176fd5c58ee05edd68