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Efficacy and Safety of Talc Pleurodesis for Malignant Pleural Effusion: A Meta-Analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 1, p e87060 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- BACKGROUND: Talc pleurodesis has been widely used to control malignant pleural effusion; however, it is still not clear whether talc pleurodesis is more effective than other local therapies. We performed a meta-analysis to evaluate the efficacy and safety of talc pleurodesis in the management of malignant pleural effusion. METHODS: PubMed, Embase, and Web of Science were searched for English-language studies of clinical controlled trials comparing talc pleurodesis with control therapies until August 8, 2013. Success rate and incidence of adverse events were evaluated. Relative risks were estimated using random- or fixed- effects model and statistical heterogeneity was assessed using I² test. RESULTS: Twenty trials involving 1,525 patients with malignant pleural effusion were included. The success rate of talc pleurodesis was significantly higher than that of control therapies (relative risk, 1.21; 95% confidence interval, 1.01-1.45; p = 0.035) with similar adverse events. In addition, thoracoscopic talc poudrage was more effective than bedside talc slurry (relative risk, 1.12; 95% confidence interval, 1.01-1.23; p = 0.026). CONCLUSIONS: The current evidences suggested the benefit for talc pleurodesis in the treatment of malignant pleural effusion. Talc pleurodesis, especially thoracoscopic talc poudrage pleurodesis, should be performed in patients with malignant pleural effusion, especially those with life-expectancy longer than one month.
- Subjects :
- Risk
medicine.medical_specialty
Anatomy and Physiology
Non-Clinical Medicine
Medical Journals
Pulmonology
Clinical Research Design
Pleural effusion
medicine.medical_treatment
Respiratory System
lcsh:Medicine
Talc
law.invention
Breast cancer
Randomized controlled trial
law
medicine
Humans
Malignant pleural effusion
Clinical Trials
lcsh:Science
Biology
Pleurodesis
Models, Statistical
Multidisciplinary
business.industry
lcsh:R
Talc pleurodesis
Pleural Diseases
respiratory system
medicine.disease
Pleural Effusion, Malignant
respiratory tract diseases
Surgery
Oncology
Meta-analysis
Medicine
lcsh:Q
Meta-Analyses
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....151ab2cd0a87049e93d9a9e9282af651