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Haptoglobin phenotype in age-related macular degeneration patients

Haptoglobin phenotype in age-related macular degeneration patients

Authors :
Andrew P. Levy
Jacob Karp
Nir Seider
Dalia Dori
Itzchak Beiran
Benjamin Miller
Rachel Miller-Lotan
Source :
American journal of ophthalmology. 136(5)
Publication Year :
2003

Abstract

Purpose To investigate a possible role of the haptoglobin phenotype in the development of exudative age-related macular degeneration (AMD) in human subjects. Design Prospective, observational, comparative population study. Methods The study was carried out in an institutional setting. All patients referred because of exudative AMD in one eye during an 18-month period were included in the study group. A group of patients treated for other ocular diseases and not having AMD in either eye served as control. Haptoglobin phenotype was determined from a blood sample drawn from each patient in both the study and control groups. The main outcome measure was the distribution of the haptoglobin phenotype in the study and control group. Results One hundred eighty-five participants were included in the study. Ninety-eight had exudative AMD, and 87 were AMD-free. The difference between the study and control groups in distribution of the haptoglobin phenotype was found to be statistically insignificant. Conclusions Our results suggest that the haptoglobin phenotype has no effect on the prevalence of exudative AMD.

Details

ISSN :
00029394
Volume :
136
Issue :
5
Database :
OpenAIRE
Journal :
American journal of ophthalmology
Accession number :
edsair.doi.dedup.....151cd7c69fa1db38541a2b7ded08a2fe