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LncRNAs in domesticated animals: from dog to livestock species
- Source :
- Mammalian Genome, Mammalian Genome, Springer Verlag, 2021, ⟨10.1007/s00335-021-09928-7⟩, Mammalian Genome, 2022, 33 (2), pp.248-270. ⟨10.1007/s00335-021-09928-7⟩
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Animal genomes are pervasively transcribed into multiple RNA molecules, of which many will not be translated into proteins. One major component of this transcribed non-coding genome is the long non-coding RNAs (lncRNAs), which are defined as transcripts longer than 200 nucleotides with low coding-potential capabilities. Domestic animals constitute a unique resource for studying the genetic and epigenetic basis of phenotypic variations involving protein-coding and non-coding RNAs, such as lncRNAs. This review presents the current knowledge regarding transcriptome-based catalogues of lncRNAs in major domesticated animals (pets and livestock species), covering a broad phylogenetic scale (from dogs to chicken), and in comparison with human and mouse lncRNA catalogues. Furthermore, we describe different methods to extract known or discover novel lncRNAs and explore comparative genomics approaches to strengthen the annotation of lncRNAs. We then detail different strategies contributing to a better understanding of lncRNA functions, from genetic studies such as GWAS to molecular biology experiments and give some case examples in domestic animals. Finally, we discuss the limitations of current lncRNA annotations and suggest research directions to improve them and their functional characterisation.
- Subjects :
- Livestock
Genome-wide association study
Computational biology
Biology
Genome
Transcriptome
Mice
03 medical and health sciences
Dogs
0302 clinical medicine
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Genetics
Animals
Epigenetics
Phylogeny
030304 developmental biology
Comparative genomics
0303 health sciences
Phylogenetic tree
RNA
Human genetics
Animals, Domestic
030220 oncology & carcinogenesis
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
RNA, Long Noncoding
Subjects
Details
- ISSN :
- 14321777 and 09388990
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Mammalian Genome
- Accession number :
- edsair.doi.dedup.....1520e29081d6c4af87ca7ecf7835e168
- Full Text :
- https://doi.org/10.1007/s00335-021-09928-7