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Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity
- Source :
- Bioactive Materials, Vol 6, Iss 10, Pp 3207-3217 (2021), Bioactive Materials
- Publication Year :
- 2021
- Publisher :
- KeAi Communications Co., Ltd., 2021.
-
Abstract
- Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity. Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches, we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects. Herein, a surface-nanoengineered antimicrobial liposome (SNAL) is developed with the morphological features of enveloped viruses, including a moderate size range, lipid-based membrane structure, and highly lipopeptide-enriched bilayer surface. The SNAL possesses virus-like infection to bacterial cells, which can mediate high-efficiency and high-selectivity bacteria binding, rapidly attack and invade bacteria via plasma membrane fusion pathway, and induce a local “burst” release of lipopeptide to produce irreversible damage of cell membrane. Remarkably, viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations (1.6–6.3 μg mL−1), high bactericidal efficiency of >99% within 2 h, >10-fold enhanced selectivity over free lipopeptide, 99.8% reduction in skin MRSA load after a single treatment, and negligible toxicity. This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials.<br />Graphical abstract Image 1
- Subjects :
- QH301-705.5
0206 medical engineering
Biomedical Engineering
02 engineering and technology
Article
Biomaterials
Cell membrane
chemistry.chemical_compound
Viral envelope
Plasma membrane fusion
medicine
Antimicrobial lipopeptides
Biology (General)
Materials of engineering and construction. Mechanics of materials
Liposome
biology
Virus-inspired mimics
Membrane structure
Lipopeptide
Virus-like infections
021001 nanoscience & nanotechnology
biology.organism_classification
Antimicrobial
020601 biomedical engineering
medicine.anatomical_structure
chemistry
Activity and selectivity
Liposomes
Biophysics
TA401-492
0210 nano-technology
Bacteria
Biotechnology
Subjects
Details
- Language :
- English
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioactive Materials
- Accession number :
- edsair.doi.dedup.....152e98b9641f8a974d0aea6ece9a169a