Back to Search Start Over

Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

Authors :
Qian Xu
Jing Wang
Xin Pan
Daojun Liu
Biyuan Wu
Jiaying Chi
Chuanbin Wu
Guilan Quan
Feiyuan Yu
Guilin Zhou
Xiaoqian Feng
Jianfeng Cai
Chao Lu
Liming Lin
Yin Shi
Source :
Bioactive Materials, Vol 6, Iss 10, Pp 3207-3217 (2021), Bioactive Materials
Publication Year :
2021
Publisher :
KeAi Communications Co., Ltd., 2021.

Abstract

Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity. Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches, we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects. Herein, a surface-nanoengineered antimicrobial liposome (SNAL) is developed with the morphological features of enveloped viruses, including a moderate size range, lipid-based membrane structure, and highly lipopeptide-enriched bilayer surface. The SNAL possesses virus-like infection to bacterial cells, which can mediate high-efficiency and high-selectivity bacteria binding, rapidly attack and invade bacteria via plasma membrane fusion pathway, and induce a local “burst” release of lipopeptide to produce irreversible damage of cell membrane. Remarkably, viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations (1.6–6.3 μg mL−1), high bactericidal efficiency of >99% within 2 h, >10-fold enhanced selectivity over free lipopeptide, 99.8% reduction in skin MRSA load after a single treatment, and negligible toxicity. This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials.<br />Graphical abstract Image 1

Details

Language :
English
Volume :
6
Issue :
10
Database :
OpenAIRE
Journal :
Bioactive Materials
Accession number :
edsair.doi.dedup.....152e98b9641f8a974d0aea6ece9a169a