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Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma
- Source :
- International Journal of Gynecological Pathology, 39, 184-192, International Journal of Gynecological Pathology, 39, 2, pp. 184-192
- Publication Year :
- 2020
-
Abstract
- Lymphogenic and hematogenic metastases are uncommon in ovarian cancer, especially at presentation. We hypothesized that MMP-14 and MMP-2, CD44, and highly sulfated chondroitin sulfate (CS-E) may be overexpressed in tumors with these metastatic patterns. These molecules are all present in the ovarian tumor microenvironment, wherein they may interact. In an ovarian cancer cohort of 44 patients with metastases in lymph nodes, spleen, and/or liver, the presence of MMP-14, MMP-2, CD44, and CS-E in both the primary tumor and the metastases was determined with immunohistochemistry and related to clinical characteristics. Immunohistochemical expression was found for MMP-14 in all primary tumors as well as in all metastases and for MMP-2 expression in most of the samples. Most primary tumors with synchronous metastases were positive for CS-E, as well as most primary tumors with metachronous lymphogenic metastases. The expression of the MMPs and CS-E in the stroma seemed to colocalize. For CD44 immunohistochemical expression, this relationship was not found. Epithelial MMP-14 on the one hand and stromal CS-E on the other hand seem to be essential players in ovarian cancer with lymphogenic and hematogenic metastases. CD44 expression is not correlated with the other markers. More research on the interaction of these molecules and their role in the process of dissimination of disease is warranted.
- Subjects :
- Adult
0301 basic medicine
Pathology
medicine.medical_specialty
Carcinoma, Ovarian Epithelial
Pathology and Forensic Medicine
Metastasis
03 medical and health sciences
Ovarian tumor
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Stroma
Biomarkers, Tumor
Matrix Metalloproteinase 14
medicine
Carcinoma
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Aged
Retrospective Studies
Aged, 80 and over
Ovarian Neoplasms
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
biology
business.industry
Chondroitin Sulfates
CD44
Obstetrics and Gynecology
Middle Aged
medicine.disease
Primary tumor
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
Immunohistochemistry
Female
Ovarian cancer
business
Subjects
Details
- ISSN :
- 02771691
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecological Pathology, 39, 184-192, International Journal of Gynecological Pathology, 39, 2, pp. 184-192
- Accession number :
- edsair.doi.dedup.....154cdb8106081418d035d2b56337c765