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Blood‐brain barrier breakdown, neuroinflammation, and cognitive decline in older adults
- Source :
- Alzheimer's & Dementia. 14:1640-1650
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Introduction Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer's disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Methods Cerebrospinal fluid and serum inflammatory markers were measured using sandwich immunoassays in 120 subjects. Least Absolute Shrinkage and Selection Operator-logistic regression selected cerebrospinal fluid and serum signatures that best classified BBB impairment defined by the cerebrospinal fluid albumin index ≥9. Linear regression examined changes in Clinical Dementia Rating sum of boxes as a function of BBB integrity at baseline. Results Mean age was 70 years, mean Mini–Mental State Examination was 27, and BBB impairment was recorded in 13.5%. BBB breakdown was associated with cognitive decline ( P = .015). Cerebrospinal fluid intercellular adhesion molecule-1, vascular endothelial growth factor, interleukin-8, serum amyloid A, macrophage derived chemokine, and gender generated an area under the curve of 0.95 for BBB impairment, and serum IL-16, VEGF-D, IL-15, and other variables generated an AUC of 0.92 for BBB impairment. Discussion BBB breakdown is associated with more rapid cognitive decline. Inflammatory mechanisms, including cell adhesion, neutrophil migration, lipid metabolism, and angiogenesis may be implicated.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Epidemiology
Apolipoprotein E4
Neuropsychological Tests
Blood–brain barrier
Cohort Studies
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Cerebrospinal fluid
Developmental Neuroscience
Internal medicine
medicine
Humans
Dementia
Cognitive Dysfunction
Serum amyloid A
Cognitive decline
Neuroinflammation
Aged
Inflammation
business.industry
Health Policy
medicine.disease
Ascorbic acid
Hyperintensity
Cerebrovascular Disorders
Psychiatry and Mental health
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Blood-Brain Barrier
Disease Progression
cardiovascular system
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi.dedup.....156552e9a6e3144e98ff192d969d6239