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Factors That Determine the Adhesive Strength in a Bioinspired Bone Tissue Adhesive

Authors :
Håkan Engqvist
Alicja Bojan
Gerard Insley
Michael Pujari-Palmer
Philip Procter
Roger Giró
Source :
ChemEngineering, Volume 4, Issue 1, ChemEngineering, Vol 4, Iss 1, p 19 (2020)
Publication Year :
2020
Publisher :
Multidisciplinary Digital Publishing Institute, 2020.

Abstract

Phosphoserine-modified cements (PMCs) are a family of wet-field tissue adhesives that bond strongly to bone and biomaterials. The present study evaluated variations in the adhesive strength using a scatter plot, failure mode, and a regression analysis of eleven factors. All single-factor, continuous-variable correlations were poor (R2 &lt<br />0.25). The linear regression model explained 31.6% of variation in adhesive strength (R2 = 0.316 p &lt<br />0.001), with bond thickness predicting an 8.5% reduction in strength per 100 &mu<br />m increase. Interestingly, PMC adhesive strength was insensitive to surface roughness (Sa 1.27&ndash<br />2.17 &mu<br />m) and the unevenness (skew) of the adhesive bond (p &gt<br />0.167, 0.171, ANOVA). Bone glued in conditions mimicking the operating theatre (e.g., the rapid fixation and minimal fixation force in fluids) produced comparable adhesive strength in laboratory conditions (2.44 vs. 1.96 MPa, p &gt<br />0.986). The failure mode correlated strongly with the adhesive strength<br />low strength PMCs (&lt<br />1 MPa) failed cohesively, while high strength (&gt<br />2 MPa) PMCs failed adhesively. Failure occurred at the interface between the amorphous surface layer and the PMC bulk. PMC bonding is sufficient for clinical application, allowing for a wide tolerance in performance conditions while maintaining a minimal bond strength of 1.5&ndash<br />2 MPa to cortical bone and metal surfaces.

Details

Language :
English
ISSN :
23057084
Database :
OpenAIRE
Journal :
ChemEngineering
Accession number :
edsair.doi.dedup.....156bfa9cb9fbdd4a33cc3b5128ded903
Full Text :
https://doi.org/10.3390/chemengineering4010019