Teaching neuroimages: brain MRI and FDG-PET in malformations of cortical development and hippocampal hypoplasia

A 16-year-old intellectually normal woman, with a history of febrile seizures, presented with focal seizures. MRI showed several regions of polymicrogyria/pachygyria, cortical heterotopia, and left hippocampal hypoplasia, associated with (interictal) FDG-PET hypometabolism (figure). Other examinations did not show evidence of tuberous sclerosis. Figure Imaging MRI shows regional, thickened and flat, …