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Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens

Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens

Authors :
Shang-Chuen Wu
Nourine A. Kamili
Marcelo Dias-Baruffi
Cassandra D. Josephson
Matthew F. Rathgeber
Melissa Y. Yeung
William J. Lane
Jianmei Wang
Hau-Ming Jan
Seth Rakoff-Nahoum
Richard D. Cummings
Sean R. Stowell
Connie M. Arthur
Source :
iScience. 25:104482
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Adaptive immunity can target a nearly infinite range of antigens, yet it is tempered by tolerogenic mechanisms that limit autoimmunity. Such immunological tolerance, however, creates a gap in adaptive immunity against microbes decorated with self-like antigens as a form of molecular mimicry. Our results demonstrate that the innate immune lectin galectin-7 (Gal-7) binds a variety of distinct microbes, all of which share features of blood group-like antigens. Gal-7 binding to each blood group expressing microbe, including strains of

Subjects

Subjects :
Multidisciplinary

Details

ISSN :
25890042
Volume :
25
Database :
OpenAIRE
Journal :
iScience
Accession number :
edsair.doi.dedup.....1586e4ca11d505598d877df497670d37
Full Text :
https://doi.org/10.1016/j.isci.2022.104482