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Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens
Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens
- Source :
- iScience. 25:104482
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Adaptive immunity can target a nearly infinite range of antigens, yet it is tempered by tolerogenic mechanisms that limit autoimmunity. Such immunological tolerance, however, creates a gap in adaptive immunity against microbes decorated with self-like antigens as a form of molecular mimicry. Our results demonstrate that the innate immune lectin galectin-7 (Gal-7) binds a variety of distinct microbes, all of which share features of blood group-like antigens. Gal-7 binding to each blood group expressing microbe, including strains of
- Subjects :
- Multidisciplinary
Subjects
Details
- ISSN :
- 25890042
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- iScience
- Accession number :
- edsair.doi.dedup.....1586e4ca11d505598d877df497670d37
- Full Text :
- https://doi.org/10.1016/j.isci.2022.104482