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The potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study
- Source :
- QJM: An International Journal of Medicine
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- Background Sleep-related movement disorders (SRMD) have been shown to increase the risk of cardiovascular diseases. However, the relationship between SRMD and stroke remains unclear. Aim To explore the relationship between SRMD and stroke in the general population. Design Two cohorts of patients with SRMD and without SRMD were followed up for the occurrence of hemorrhagic and ischemic stroke. Methods The study cohort enrolled 604 patients who were initially diagnosed as SRMD between 2000 and 2005. 2,416 age- and sex-matched patients without prior stroke were selected as the comparison cohort. A Cox-proportional hazard regression analysis was performed for multivariate adjustment. Results Patients with SRMD had a higher risk for developing all-cause stroke [adjusted hazard ratio (HR) = 2.29, 95% confidence interval (CI) = 1.42–3.80]. Patients of below 45 years old had the greatest stroke risk (HR = 4.03, 95% CI = 3.11–5.62), followed by patients aged ≥65 years (HR = 2.64, 95% CI = 1.12–3.44) and 45–64 years (HR = 1.07, 95% CI = 1.02–1.71). The age-stratified analysis suggested that the increased risk of hemorrhagic stroke was more significant than ischemic stroke among all age groups. Furthermore, males with SRMD were at greater risk to develop all-cause stroke (HR = 2.98, 95% CI = 1.74–4.50) than that of females (HR = 1.94, 95% CI = 1.01–3.77). Conclusions Patients with SRMD were found to have an increased risk of all-cause stroke along with a higher possibility of hemorrhagic stroke over ischemic stroke.
- Subjects :
- Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
Longitudinal study
Movement disorders
National Health Programs
Population
Taiwan
Stroke risk
03 medical and health sciences
Age Distribution
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Longitudinal Studies
030212 general & internal medicine
Sex Distribution
education
Stroke
Aged
Proportional Hazards Models
education.field_of_study
Movement Disorders
business.industry
Hazard ratio
General Medicine
Middle Aged
medicine.disease
Original Papers
Confidence interval
Multivariate Analysis
Cohort
Physical therapy
Female
medicine.symptom
business
Intracranial Hemorrhages
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14602393 and 14602725
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- QJM: An International Journal of Medicine
- Accession number :
- edsair.doi.dedup.....15955f80fa220309529f5f3a3cee5d33