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Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
- Source :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Research, 2020.
-
Abstract
- The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fungi, or both to differentiate the causal role of fungi on microbiome assembly, immune development, susceptibility to colitis, and airway inflammation. Fungal colonization promotes major shifts in bacterial microbiome ecology, and has an independent effect on innate and adaptive immune development in young mice. While exclusive fungal colonization is insufficient to elicit overt dextran sulfate sodium-induced colitis, bacterial and fungal co-colonization increase colonic inflammation. Ovalbumin-induced airway inflammation reveals that bacterial, but not fungal colonization is necessary to decrease airway inflammation, yet fungi selectively promotes macrophage infiltration in the airway. Together, our findings demonstrate a causal role for fungi in microbial ecology and host immune functionality, and therefore prompt the inclusion of fungi in therapeutic approaches aimed at modulating early life microbiomes.<br />The immunomodulatory role of commensal gut fungi and interactions with bacteria remain unclear. Here, using germ-free mice colonized with defined species of bacteria and fungi, the authors find that fungal colonization induces changes in bacterial microbiome ecology while having an independent effect on innate and adaptive immunity in mice.
- Subjects :
- 0301 basic medicine
Ovalbumin
Science
030106 microbiology
General Physics and Astronomy
Inflammation
Bacterial Physiological Phenomena
General Biochemistry, Genetics and Molecular Biology
Article
Microbiology
03 medical and health sciences
Feces
Immune system
Microbial ecology
medicine
Metabolome
Animals
Germ-Free Life
Humans
VDP::Medisinske Fag: 700
Microbiome
Colitis
lcsh:Science
Multidisciplinary
biology
Dextran Sulfate
Fungi
General Chemistry
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Intestines
Mice, Inbred C57BL
VDP::Medical disciplines: 700
030104 developmental biology
Immune System
lcsh:Q
Female
medicine.symptom
Bacteria
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
- Accession number :
- edsair.doi.dedup.....16366fc1aa80f9bfb6de62b884a3b361