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Mutations of acetylcholinesterase which confer insecticide resistance in insect populations
- Source :
- Chemico-Biological Interactions, Chemico-Biological Interactions, Elsevier, 2005, 157-158, pp.257-261, Chemico-Biological Interactions, Elsevier, 2005, 157-158, pp.257-61. ⟨10.1016/j.cbi.2005.10.040⟩
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Resistance-modified acetylcholinesterases have been described in many insect species and sequencing of their genes has allowed several point mutations to be described. Most mutations line the active site gorge. Each mutation provides a specific resistance pattern: it confers resistance to one insecticide but may increase sensitivity to another. Most mutations alter hydrolysis of the substrate by decreasing the rate of enzyme deacetylation and by diminishing the stability of the enzyme. Mutations are often found in combination in the same protein. This has several consequences: it increases the level of resistance, it enlarges the spectrum of resistance and it may restore the catalytic efficiency of the enzyme. Natural populations are heterogeneous, composed of a mixture of different alleles.
- Subjects :
- 0106 biological sciences
Insecticides
MESH: Enzyme Stability
Insecta
DNA Mutational Analysis
MESH: Base Sequence
Toxicology
medicine.disease_cause
01 natural sciences
Substrate Specificity
Insecticide Resistance
chemistry.chemical_compound
MESH: Insects
Enzyme Stability
MESH: Animals
MESH: DNA Mutational Analysis
[SDV.EE]Life Sciences [q-bio]/Ecology, environment
Genetics
chemistry.chemical_classification
0303 health sciences
Mutation
biology
Hydrolysis
General Medicine
Acetylcholinesterase
MESH: Hydrolysis
MESH: Mutation
MESH: Population Density
03 medical and health sciences
medicine
Animals
MESH: Insecticide Resistance
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Allele
Gene
Alleles
030304 developmental biology
Population Density
Base Sequence
MESH: Alleles
Point mutation
Active site
MESH: Acetylcholinesterase
MESH: Insecticides
010602 entomology
Enzyme
chemistry
Acetylation
biology.protein
MESH: Substrate Specificity
Subjects
Details
- ISSN :
- 00092797
- Database :
- OpenAIRE
- Journal :
- Chemico-Biological Interactions
- Accession number :
- edsair.doi.dedup.....1665fb199b911f5de0be770f562f7729