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The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
- Source :
- Viruses; Volume 14; Issue 9; Pages: 1954
- Publication Year :
- 2022
- Publisher :
- MDPI, 2022.
-
Abstract
- Altres ajuts: Generalitat de Catalunya, programa Cerca RTI2018-100887-B-I00 Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G vaccine is a novel candidate that confers robust immunity and shows DIVA capabilities. The present study assessed the immune response elicited by FlagT4G and its capacity to protect pigs for a short time after vaccination. Five days after a single dose of FlagT4G vaccine, animals were challenged with a highly virulent CSFV strain. A strong, but regulated, interferon-α response was found after vaccination. Vaccinated animals showed clinical and virological protection against the challenge, in the absence of antibody response at 5 days post-vaccination. Upon challenge, a rapid rise in the titers of CSFV neutralizing antibodies and an increase in the IFN-γ producing cells were noticed in all vaccinated-challenged pigs. Meanwhile, unvaccinated pigs showed severe clinical signs and high viral replication, being euthanized before the end of the trial. These animals were unable to generate neutralizing antibodies and IFN-γ responses after the CSFV challenge. The results from the present study assert the fast and efficient protection by FlagT4G, a highly promising tool for CSFV control worldwide.
- Subjects :
- Innate immunity
Swine
Vaccination
Vaccine efficacy
Marker vaccine
Interferon-alpha
Viral Vaccines
FlagT4G
Antibodies, Viral
Antibodies, Neutralizing
Classical Swine Fever
Virological protection
Infectious Diseases
Classical Swine Fever Virus
vaccine efficacy
CSFV
innate immunity
marker vaccine
virological protection
antibody response
Virology
Antibody response
Animals
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Viruses; Volume 14; Issue 9; Pages: 1954
- Accession number :
- edsair.doi.dedup.....167a6aa0313c22c4d558fa27fd7d0a23