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A major role for common genetic variation in anxiety disorders

Authors :: Preben Bo Mortensen
Matthew Hotopf
Christopher Rayner
Thalia C. Eley
Thomas Werge
Manuel Mattheisen
Kristin K. Nicodemus
David M. Hougaard
Ole Mors
Anders D. Børglum
Sandra Meier
Christopher Hübel
Merete Nordentoft
Carol Kan
Kirstin L. Purves
Shing Wan Cho
Katrina A. S. Davis
Jonathan R. I. Coleman
Marie Bækvad-Hansen
Andrew M. McIntosh
Helena Gaspar
Jonas Bybjerg-Grauholm
Gerome Breen
Jürgen Deckert
John M. Hettema
Rosa Cheesman
Source :: Purves, K L, Coleman, J R I, Meier, S M, Rayner, C, Davis, K A S, Cheesman, R, Bækvad-hansen, M, Børglum, A D, Wan Cho, S, Jürgen Deckert, J, Gaspar, H A, Bybjerg-grauholm, J, Hettema, J M, Hotopf, M, Hougaard, D, Hübel, C, Kan, C, Mcintosh, A M, Mors, O, Bo Mortensen, P, Nordentoft, M, Werge, T, Nicodemus, K K, Mattheisen, M, Breen, G & Eley, T C 2019, ' A major role for common genetic variation in anxiety disorders ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0559-1, Purves, K, Coleman, J R I, Meier, S M, Rayner, C D, Davis, K A S, Cheesman, R, Bækvad-Hansen, M, Børglum, A D, Choi, S W, Deckert, J, Gaspar, H A, Bybjerg-Grauholm, J, Hettema, J M, Hotopf, M, Hougaard, D M, Huebel, C, Kan, C, McIntosh, A M, Mors, O, Mortensen, P B, Nordentoft, M, Werge, T, Nicodemus, K K, Mattheisen, M, Breen, G D & Eley, T C 2020, ' A major role for common genetic variation in anxiety disorders ', Molecular Psychiatry, vol. 25, no. 12, pp. 3292-3303 . https://doi.org/10.1038/s41380-019-0559-1, Purves, K L, Coleman, J R I, Meier, S M, Rayner, C, Davis, K A S, Cheesman, R, Bækvad-Hansen, M, Børglum, A D, Wan Cho, S, Jürgen Deckert, J, Gaspar, H A, Bybjerg-Grauholm, J, Hettema, J M, Hotopf, M, Hougaard, D, Hübel, C, Kan, C, McIntosh, A M, Mors, O, Bo Mortensen, P, Nordentoft, M, Werge, T, Nicodemus, K K, Mattheisen, M, Breen, G & Eley, T C 2020, ' A major role for common genetic variation in anxiety disorders ', Molecular Psychiatry, vol. 25, pp. 3292-3303 . https://doi.org/10.1038/s41380-019-0559-1, Mol Psychiatry
Publication Year :: 2019
Publisher :: Springer Science and Business Media LLC, 2019.
Abstract: Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n = 83 565) and an additional Current Anxiety Symptoms (n= 77 125) analysis. The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.