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JBIR-78 and JBIR-95: phenylacetylated peptides isolated from Kibdelosporangium sp. AK-AA56
- Source :
- Journal of natural products. 75(2)
- Publication Year :
- 2012
-
Abstract
- The search for metabolites of Kibdelosporangium sp. AK-AA56 resulted in the discovery of novel N-phenylacetylated peptides, JBIR-78 (1) and JBIR-95 (2). Compounds 1 and 2 were established to be N-phenylacetylated heptapeptides by extensive NMR and HRESIMS analyses. The absolute configuration of the standard amino acids including a cysteic acid moiety was determined using Marfey’s method on the acid hydrolysates of 1 and 2. The relative and absolute configurations of a nonstandard amino acid, β-hydroxyleucine, were elucidated using the J-based and modified Mosher’s methods, respectively. In an antimicrobial test, 1 showed antibacterial activity against Micrococcus luteus.
- Subjects :
- Stereochemistry
Pharmaceutical Science
Cysteic acid
Microbial Sensitivity Tests
Hydrolysate
Analytical Chemistry
Micrococcus
chemistry.chemical_compound
Japan
Drug Discovery
Actinomycetales
Moiety
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
chemistry.chemical_classification
biology
Molecular Structure
Chemistry
Organic Chemistry
Absolute configuration
biology.organism_classification
Antimicrobial
Amino acid
Anti-Bacterial Agents
Complementary and alternative medicine
Molecular Medicine
Micrococcus luteus
Antibacterial activity
Peptides
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 75
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....169fe1a8e2c644ef49333cca84bd0793