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Quantitative assessment of interstitial lung disease in Sjögren's syndrome
- Source :
- ABACUS. Repositorio de Producción Científica, Universidad Europea (UEM), PLoS ONE, Vol 14, Iss 11, p e0224772 (2019), PLoS ONE
- Publication Year :
- 2019
-
Abstract
- Background: Interstitial lung disease (ILD) is a frequent manifestation of Sjögren's syndrome (SS), an autoimmune disease of salivary and lacrimal glands, and affects approximately 20% of patients. No clinical or serological features appear to be useful to predict its presence, severity or progression, and chest high-resolution computed tomography (CT) remains the gold standard for diagnosis. Semiquantitative CT (SQCT) based on visual assessment (Goh and Taouli scoring) can estimate ILD extent, although it is burdened by relevant intra- and interobserver variability. Quantitative chest CT (QCT) is a promising alternative modality to assess ILD severity. Aim: To determine whether QCT assessment can identify extensive or limited lung disease in patients with SS and ILD. Methods: This multi-center, cross-sectional and retrospective study enrolled patients with SS and a chest CT scan. SQCT assessment was carried out in a blinded and centralized manner to calculate both Goh and Taouli scores. An operator-independent analysis of all CT scans with the open-source software platform Horos was used to evaluate the QCT indices. Patients were classified according to the extent of ILD and differences in QCT index distribution were investigated with non-parametric tests. Results: From a total of 102 consecutive patients with SS, the prevalence of ILD was 35.3% (36/102). There was a statistically significant difference in QCT index distribution between the SS with ILD and SS without ILD groups (p20% (by Goh score) had a QCT index statistically different from those with limited ILD extent (p
- Subjects :
- Male
Pulmonology
Pulmonary Function
Computed tomography
Salivary Glands
Pulmonary function testing
Diagnostic Radiology
0302 clinical medicine
Quantitative assessment
Medicine and Health Sciences
Tecnología médica
Tomography
Statistical Data
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Statistics
Interstitial lung disease
Middle Aged
respiratory system
Respiratory Function Tests
Sjogren's Syndrome
Physical Sciences
Medicine
Female
Anatomy
Research Article
Statistical Distributions
musculoskeletal diseases
Imaging Techniques
Science
Immunology
Investigación médica
Neuroimaging
Interstitial Lung Diseases
Research and Analysis Methods
behavioral disciplines and activities
Sensitivity and Specificity
Autoimmune Diseases
03 medical and health sciences
Exocrine Glands
Enfermedades pulmonares intersticiales
Diagnostic Medicine
Enfermedades autoinmunes
medicine
Humans
Aged
030203 arthritis & rheumatology
Autoimmune disease
business.industry
Biology and Life Sciences
Retrospective cohort study
Gold standard (test)
Pneumonia
medicine.disease
Probability Theory
Computed Axial Tomography
respiratory tract diseases
body regions
030228 respiratory system
Síndrome de Sjögren
Clinical Immunology
Clinical Medicine
business
Nuclear medicine
Lung Diseases, Interstitial
Tomography, X-Ray Computed
Digestive System
Mathematics
Neuroscience
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ABACUS. Repositorio de Producción Científica, Universidad Europea (UEM), PLoS ONE, Vol 14, Iss 11, p e0224772 (2019), PLoS ONE
- Accession number :
- edsair.doi.dedup.....16afd88a8fe196c09e649b52b7983f6d