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Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model
- Source :
- Nanotoxicology. 10(7)
- Publication Year :
- 2015
-
Abstract
- Despite promising environmental applications for nano zerovalent iron (nZVI), concerns remain about the potential accumulation and toxic effects of nZVI particles. Here, we use an alveolar-capillary co-culture model to investigate a possible link between low-level epithelial exposure to nZVI and pulmonary and cardiovascular toxicity. While nZVI was unable to pass through the epithelial barrier into the endothelium, nZVI exposure did cause oxidative and inflammatory responses in both epithelial and endothelial cells. Therefore, toxic effects induced by nZVI are not restricted to epithelial cells but can be transferred into the endothelium. Communication between A549 and EA.hy926 cells is responsible for amplification of nZVI-induced toxic responses. Decreases in transepithelial electrical resistance and zonula occludens proteins after epithelial exposure to nZVI impaired epithelial barrier integrity. Increases in oxidized α1-antitrypsin and oxidized low-density lipoprotein in the co-culture model suggest that nZVI exposure increases the risk of chronic obstructive pulmonary disease and atherosclerosis. Therefore, inhalation of nZVI has the potential to induce cardiovascular disease through oxidative and inflammatory mediators produced from the damaged lung epithelium in chronic lung diseases.
- Subjects :
- 0301 basic medicine
Endothelium
Cell Survival
Surface Properties
Iron
Biomedical Engineering
Inflammation
Nanotechnology
Oxidative phosphorylation
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
Cardiovascular System
Models, Biological
03 medical and health sciences
medicine
Humans
Lung
0105 earth and related environmental sciences
Inhalation
Chemistry
Endothelial Cells
Epithelial Cells
In vitro
Coculture Techniques
Cell biology
Lipoproteins, LDL
030104 developmental biology
medicine.anatomical_structure
A549 Cells
alpha 1-Antitrypsin
Nanoparticles
medicine.symptom
Oxidation-Reduction
Oxidative stress
Lipoprotein
Subjects
Details
- ISSN :
- 17435404
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nanotoxicology
- Accession number :
- edsair.doi.dedup.....16cd24597489a07c7e65b674fc79ee65