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Effect of glycemic index on whole-body substrate oxidation in obese women
- Source :
- International Journal of Obesity. 29:108-114
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Glycemic index is hypothesized to determine fuel partitioning through serum plasma insulin modifications induced by dietary carbohydrates, thereby modulating fat accretion or oxidation.To assess the glycemic effects on postprandial fuel oxidation and blood response.In all, 12 obese women were fed on a randomized crossover design with two test meals (breakfast+lunch). High- or low-glycemic meals were provided on separate days. Energy intake on high-glycemic meal was 7758+/-148 kJ and for low-glycemic meal was 7806+/-179 kJ. Carbohydrates supplied were 273+/-5 and 275+/-6 g, respectively. Macronutrient distribution was 55% carbohydrates, 30% fat and 15% protein. Fuel oxidation was measured continuously in a respiratory chamber for 10 h. Serum glucose, free fatty acids (FFA), insulin and glucagon samples were taken for 5 h after breakfast.Glucose AUC changed significantly in response to different glycemic breakfast. Low- vs high-glycemic breakfast was 211+/-84 and 379+/-164 mmol/l (P0.05). Similarly, insulin changed from 94+/-37 and 170+/-87 nmol/l (P0.05), respectively. The rate of increment for serum glucose and insulin reached by the high- vs low-glycemic meal was 1.8 times more with the high-glycemic breakfast. Serum FFA were similarly suppressed by both meal types by 3 h after meal intake, but then raised significantly more with the low-glycemic meal by the fourth and fifth hour (P0.05). Plasma glucagon did not show a significant variation with glycemic index. Carbohydrate and fat oxidation was not modified by glycemic meal characteristics, being virtually the same for low- vs high-glycemic comparisons in the 5 h following breakfast and lunch (P=NS).This study demonstrates that dietary glycemic characteristics were unable to modify fuel partitioning in sedentary obese women.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Medicine (miscellaneous)
Fatty Acids, Nonesterified
Glucagon
Internal medicine
Dietary Carbohydrates
medicine
Humans
Insulin
Obesity
Glycemic
Meal
Cross-Over Studies
Nutrition and Dietetics
business.industry
digestive, oral, and skin physiology
Calorimetry, Indirect
Carbohydrate
Postprandial Period
medicine.disease
Endocrinology
Glycemic index
Postprandial
Glycemic Index
Area Under Curve
Female
business
Oxidation-Reduction
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....16d81f888d1b9047a3c10d34992bc2ab